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Nepenthe was a fantasy poetry fanzine by Earl Singleton.

Nepenthe was published at the M.I.T. Graduate House, Cambridge, Massachusetts, U.S.A.The first issue of Nepenthe appeared in December 1940. The title page carries a dedication that reads:

the first issue of Nepenthe
is for Trudy--
if we are not mistaken
was at the Chicon.

"Trudy" is in all probability, Gertrude Kuslan, known as 'Trudy', since it was noted at the time that she and Earl Singleton were romantically involved..

Contributors included Louis Russell Chauvenet, Del Cross, Ian Davies, Corinne Ellsworth, E, Everett Evans (Nova), Larry B. Farsaci (The Golden Atom), John Franois, Paul Freehafer (Polaris), Curl Gradient, B.M. Hendrick, Jr., Richard Kraft, Arthur Lambert, Allan Lang, Grady L. McMurtry, A. Merritt, Jack Chapman Miske (Bizarre, Scienti-Snaps), P. Tex Sigma, Charles R. Tanner, Dale Tarr, Harry Warner, Jr. (Horizons), and Stanley G. Weinbaum.

The cover art was by Marie Johnson and issue #1 included illustrations by Grady L. McMurtrey.

The second issue appeared in Spring 1941.

At this time, A. Merritt wrote to Roy V. Hunt that " If Singleton "can only keep it up, he's got something."

Earl Singleton was also co-editor of FanFare.

In his article "The Stranger Club, for the January 1987 Noreascon Three Progress Report, Singleton's co-editor on FanFare writes, "Like a comet, Henry Peter Earl Singleton dazzled fandom for less than a year, then abruptly was gone. Besides improving and strengthening the literate side of Fanfare, he brought out his own zine, Nepenthe, a fine collection of fantasy poetry that is still a landmark in that area. He attended Chicon I with me in 1940 and staged a whirlwind romance with Trudy Kuslan, one of the very few female fen of that time. Perhaps her head was quite turned because he was so unlike the "typical" fan. Even taller and handsomer than his fellow Texan, Dale Hart (who was also a great hand with the ladies), he was the envy of the rest of us wimpy pimply adolescents."