Mainstream was a science fiction fanzine by Suzanne 'Suzle' Tompkins and Jerry Kaufman.
Previously, Suzle and Jerry had published The Spanish Inquisition in the 1970s. Mainstream was their return to fanzine publishing in the 1980's.
Contributing artists included Jay Kinney, Bill Rotsler, Dan Steffan (Boonfark), Steve Stiles, and Arthur Thomson (The ATom Anthology).
Contributors of writing included Gregory Benford, Dave Langford (Ansible), Loren MacGregor, Jessica Amanda Salmonson (Windhaven), and Jon Singer.