Hopper became famous at the age of 16, after photos of her and her zine were featured in "Newsweek" and the "L.A. Weekly". This was followed by articles in "Seventeen", "City Pages", and "The Minneapolis Star-Tribune" (where her mother worked as an Assistant Managing Editor).
Hopper was originally a member of Minneapolis Riot Grrrl. She had a falling-out with other members of the organization as the result of statements that Hopper had made to members of the mainstream press. Hopper was criticized for acting as a spokesperson for Riot Grrrl, which had declared a media blackout.
As a high school student, Hopper interned at Amphetamine-Reptile Records, and wrote zine reviews for Cake.
Hopper has worked as a publicity agent for The Alkaline Trio, and other rising alternative acts. Her public relations company, Hopper PR (formerly Hyper PR), was founded in 1997.
Jessica Hopper continued to publish Hit It Or Quit It on an irregular basis after moving to Chicago. She was a columnist for Punk Planet. Her writing has also appeared in Venus, Bust, Spin, the Village Voice, Pitchfork, and the Chicago Reader.